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1 Symptoms of low testosterone can include: Persistent fatigue or low energy 2 Reduced sex drive 3 Difficulty building or maintaining muscle mass 4 Increased body fat, particularly around the abdomen 5 Mood changes, including irritability or depression 6 Brain fog or difficulty concentrating 7 Weaker erections 8 or sexual dysfunction 9 Poor sleep quality 10 After TRT: Benefits & Timeline Men starting TRT don’t wake up transformed overnight — but the timeline tends to move faster than most expect