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Iron overload promotes the polarization of M1 macrophages and increases the levels of M1 macrophage markers (IL-6, TNF-α, and IL-1β) ( As the first line of host defense against invading pathogens, neutrophils can be the first type of innate immune cells reaching the RA synovial joints to drive inflammation by producing chemokines, ROS, and neutrophil extracellular traps (NETs) ( T cells are the leading inflammatory cells in RA synovial tissues

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