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Additionally, the immunoregulatory function of GABA participates in comorbidity mechanisms, and its deficiency leads to elevated pro-inflammatory cytokine levels in the intestinal mucosa of comorbid patients, forming a vicious cycle of inflammation-neurotransmitter dysregulation (Seifi et al., 2018)
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Research suggests that group II and group III metabotropic receptors can occur presynaptically, where they function as autoreceptors to block glutamate release ( Figure 4-23 )
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