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At 24- to 72-h post-bolus, NAC concentrations ranged from 17.0 ± 2.2 to 16.8 ± 3.3 μg/mL in serum and 269.3 ± 113.0 to 467.9 ± 262.7 ng/mL in CSF
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The key contribution of mGSH in preserving cell viability was first proposed by Meredith and Reed (98, 99) on the basis of the greatly increased death of hepatocytes when both GSH pools were experimentally depleted compared with cells with losses of cytoplasmic GSH alone
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