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We do not know what fraction reaches systemic circulation in humans, and "detectable GI effect" does not equal "adequate systemic bioavailability for joint repair." The acetate salt versus free acid labeling problem

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145,146 Multiple clinical trials indicate ashwagandha may have positive effects on semen parameters, such as semen volume, sperm concentration, and sperm motility, and may help reduce oxidative stress, normalize male reproductive hormones, and increase pregnancy rates in couples being treated for male infertility

amino acid transport and catabolism of reactive oxygen species