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When administered systemically via injection, these effects can benefit skin throughout the body, not just where topical products are applied

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In this study, we identify SIRT7 as a previously unrecognized endogenous protective factor and demonstrate that SIRT7 suppresses aneurysm formation by maintaining the VSMC contractile phenotype through site-specific deacetylation of SRF and that activation of SIRT7 using the NAD⁺ precursor NMN significantly attenuates aortic dilation, establishing a mechanistically grounded and potentially translatable therapeutic strategy for AAA