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The administration of n-3 PUFAs in the diet to dehydroepiandrosterone-treated mice activated Hippo signaling and YAP1 exocytosis, and suppressed NRF2, a protein that regulates critical ferroptosis-related genes ( GPX4 , GSS , TFRC , HMOX1 , and others) [325], leading to the promotion of ferroptosis in ovarian granulosa cells
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