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PUFAs can inhibit lipogenic gene transcription by downregulating the expression SREBPs [132, 133, 134, 135] and act as antagonists of liver X receptors (LXR) [136, 137] and as agonists for PPARs [122, 123, 124, 138, 139]
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Clinical trials are underway to explore its potential therapeutic applications in humans, including its use in tendon and ligament repair, inflammatory bowel disease, and neurodegenerative disorders
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