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In vitro studies with HEK cells stably transfected with various UGT1A6 amino acid variants indicate that the UGT1A6 *2 genotype had a 60% higher glucuronidation activity than the UGT1A6*1 variant [21]
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That’s because a 500mg dose of powder amounts to 439mg of berberine, which doesn’t exactly align with a clinical dose
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