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TL;DR: As we age, our skin loses energy and its ability to repair itself

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Waddington coined the term epigenetics in 1942 as pertaining to epigenesis , in parallel to Valentin Haecker's 'phenogenetics' ( Phänogenetik [14] Epigenesis in the context of the biology of that period referred to the differentiation of cells from their initial totipotent state during embryonic development