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These studies were conducted in a mouse model of compression SCI, in which SF (5 mg/kg i.p.) was administered 1 h after injury [250], and in a rat model of contusion SCI, in which SF (5 mg/kg i.p.) was administered 15 min after injury and once daily for 3 days thereafter [249]

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Substitution of valine with norleucine in the first position enhanced activity [85]