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A diagnosis of PA first requires demonstration of megaloblastic anemia by conducting a full blood count and blood smear, which evaluates the mean corpuscular volume (MCV), as well the mean corpuscular hemoglobin concentration (MCHC)
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However, mast cell tumors in dogs, soft tissue sarcoma, leukemia, multiple myeloma, and bronchoalveolar carcinoma (a type of lung cancer in dogs) may also trigger IMHA
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