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Paracellular permeability and tight junction regulation in gut health and disease | Nature Reviews Gastroenterology & Hepatology

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A significant risk factor of CKD is an unhealthy diet mixed with MSG, which led to obstructive nephropathy, including complete or incomplete blockage of kidneys with a reduced level of stone inhibitors (e.g., citrate, magnesium, etc.) followed by alkalinization of urine [82,85]