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2.2 Pathogenesis and pathophysiology of hyperuricemia Hyperuricemia is the precursor state to gout, but its pathophysiological impact extends far beyond the joints, involving multiple systems, including cardiovascular diseases, chronic kidney disease, and metabolic disorders (Wang Q

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[DOI] [PMC free article] [PubMed] [Google Scholar] 445.Voorneveld P.W., Kodach L.L., Jacobs R.J., Liv N., Zonnevylle A.C., Hoogenboom J.P., Biemond I., Verspaget H.W., Hommes D.W., De Rooij K