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Similarly, activation of CB 1 Rs and CB 2 Rs by synthetic cannabinoids [i.e., arachidonyl-2 ′ -chloroethylamide (ACEA) and HU-308, respectively] reduced nitric oxide, TNF-⍺, IL-1β and IL-6 release from spontaneous immortalized microglia (SIM)-A9 cells in culture (Young and Denovan-Wright, 2022a)