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Abbreviations AD Alzheimer’s disease ALS Amyotrophic lateral sclerosis AMPK AMP-activated protein kinase BBB Blood-brain barrier CNS Central nerve system EAAT-1 Excitatory amino acid transporter 1 EAE Experimental allergic encephalomyelitis H 2 O 2 Hydrogen peroxide MCI Mild cognitive impairment MS Multiple sclerosis MSU Monosodium urate mTOR Mammalian target of rapamycin NO Nitric oxide ONOO − Peroxynitrite PD Parkinson’s disease RNS Reactive nitrogen species ROS Reactive oxygen species SCI Spinal cord injury SOD Superoxide dismutase TFEB Transcription factor EB TLR Toll-like receptor UA Uric acid VEGF Vascular endothelial growth factor XO Xanthine oxidase Authors’ contributions LX, PW and JL conceptualized the review

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