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First, treatment with SF (5 μM for 24 h) increased frataxin protein expression, promoted axonal re-growth in frataxin-silenced motor neurons and restored Nrf2 transcriptional activity in fibroblasts from patients with FRDA (99)

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There are a several tools that have been developed to detect DMRs for WGBS, including: methylKit [108], DMRcaller [107], DSS [109], methylSig [110], BiSeq [111], bsseq [112], methylPipe [113], RnBeads [114], BEAT [115] or M3D [116]