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Collectively, the epigenetic modifications to DNA, RNA, and histone would be greatly affected by varying the access to epigenetic enzyme co-factors, such as SAM and ferrous, that may be influenced by Ergothioneine
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Potential comparative endpoints include: Copper affinity Coordination chemistry Stability Cellular uptake Gene-expression patterns Protein interactions These comparisons can help characterize sequence-dependent differences in copper-peptide behavior
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