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240 Overexpressed parkin interacts with the p53 promoter, which disturbs the transactivation of the p53 promoter and promotes DNA binding

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The kinetics of fluorescence loss could be approximated in all cases by a mono-exponential decay function with t 1/2 ∼15 s (Supplementary Figs 2 and 3, Supplementary Table 1 and Supplementary Note 1), except a small deviation for F45L where we obtained t 1/2 of ∼20 s (Supplementary Fig