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However, native amylin has several limitations as a therapeutic agent: it has a very short half-life requiring multiple daily injections, it has poor solubility and a tendency to aggregate and form amyloid fibrils (which is actually implicated in beta cell dysfunction in type 2 diabetes), and its pharmacokinetic properties are suboptimal for convenient patient use

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Some might not possess adequate training, or they might not be interested in this area of the profession