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These data further suggest neurogenesis, microglial activation, glucocorticoid signaling, as well as synaptic transmission and neural plasticity in the HPC, amygdala and mPFC as potential mechanisms

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At the molecular level, KOA chondrocytes exhibit a distinct ferroptosis-related signature: upregulation of TFR1/TFRC enhances cellular iron uptake, while downregulation of FPN1 and FTH1 impairs iron export and storage, collectively promoting labile iron pool accumulation (He et al., 2023)