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In colon adenocarcinoma cells, NNK increases nuclear factor-kappa B (NF- B) affinity as well as the cancer-promoting homomeric nicotinic acetylcholine receptor (nAChR), 7-nAChR
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This is the first time as we know that frameshift and/or nonsense mutation in human TSHR is modeled in a mammalian system at whole organism level
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