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6,17,18 The term ‘Swiss cheese appearance’ refers to the presence of large, seemingly empty vacuolar spaces surrounded by dense fibrous tissue

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Cell lysis and immunoblot Histone extracts were prepared using an EpiQuik Total Histone Extraction Kit (EpiGentek, OP-0006-100) according to the manufacturer’s instructions and quantified using DC Protein Assay Kit (Bio-Rad, 5000111)

pigmentation and discoloration