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One of the most important advantages of aptamers over antigen/antibody can be the ease of modification and stabilization methods [255], the specificity of their binding, stability to above temperatures, ultra-high stability to pH changes and different salt concentrations, very small size, very easy synthesis, and the possibility of long-term storage

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Activation of synaptic NMDARs can induce neuronal survival through Ca 2+ -mediated signal transduction pathways, whereas overactivation of extrasynaptic pathways can induce neuronal death (Stefanie et al., 2010)