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While improvements in acute medical interventions and neurosurgical protocols have enhanced early survival, the overall burden of TBI remains disproportionately high—particularly in low- and middle-income settings (Gu et al., 2025)

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Relevant studies were identified through a comprehensive search, primarily of PubMed/MEDLINE (Medical Retrieval Analysis and Retrieval System Online), Embase, Scopus, and other methods using the following search terms: "Parkinson's disease AND (pharmacotherapy OR therapeutics OR treatments OR drugs OR medication OR intervention OR therapy OR neuroprotection OR disease-modifying OR symptomatic treatment OR novel therapy OR repurposed drugs OR clinical trials OR experimental treatment OR adjunct therapy OR dopamine replacement OR neurorestoration OR neuroinflammation OR gene therapy OR targeted therapy OR small molecules OR biologics OR immunotherapy OR regenerative medicine OR gut microbiome OR drug delivery OR combination therapy OR non-dopaminergic therapy)." The search was limited to articles published from 2000 to 2025 to ensure the inclusion of the most recent advances in PD treatment