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GS-conjugates are actively transported out of cells by efflux transporters including MRP1 and P-glycoprotein belonging to the superfamily of ATP-binding cassette transporters 70–72

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However, a delay in neuronal differentiation and gliogenesis was later reported in the spinal cord of Gdf11 -null mice, suggesting that GDF11 promotes the temporal progression of neurogenesis in the developing spinal cord 57