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Although caffeine content is lower than in brewed coffee (typically 5-16 mg per 200-400 mg dose versus 80-100 mg in a cup of coffee), caffeine-sensitive individuals may experience [4][26][41]: Headache Nervousness and irritability Insomnia Gastrointestinal discomfort (nausea, diarrhea) Elevated heart rate (tachycardia) Jitteriness These side effects have NOT been significantly elevated over placebo in clinical studies using standard doses (200-500 mg/day), but individual susceptibility varies [26]