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Figure 1a shows the representative LC–MS profiles of isoDG , DG , and NG underwent a reaction in D 2 O/pyridine/Ac 2 O (1:3:3, v/v/v) or H 2 O/pyridine/Ac 2 O (1:3:3, v/v/v) at room temperature for 30 min, followed by treatment with 0.35% hydrazine at the same temperature for another 30 min