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With regard to the anti- Trypanosoma activity of isoquinoline-based compounds, Cullen and co-workers evaluated the biological potency of a series of 2-methyl-1,2,3,4-tetrahydroisoquinoline-4,6-dioles modified at the 1, 2, 4, and 6 positions of the heterocyclic core [192]
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Irisin mitigates oxidative stress, chondrocyte dysfunction and osteoarthritis development through regulating mitochondrial integrity and autophagy
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