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INTRODUCTION As one of the driving forces behind the cellular detoxification machinery, glutathione S -transferases (GSTs) and especially the pi class glutathione S -transferase P1 (GSTP1) is currently in the focus of the cancer research community, evaluating the relevance of GSTP1 epimutations for cancer development and its potential as a major epigenetic cancer biomarker

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The second is that chemicals or mixtures for testing are applied directly to cells, which avoids complicated whole organism processes such as absorpton, transportation, transformation, and excretion

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