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After reviewing five eligible randomized clinical trials involving 497 total participants, the authors found that berberine and silymarin coadministration could lead to an "advantageous improvement in lipid and glucose profile" — namely, it could lower total cholesterol, low-density lipoprotein ("bad") cholesterol, and triglycerides while increasing high-density lipoprotein ("good") cholesterol.43 Such impacts are why berberine may be particularly useful to people with type 2 diabetes