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This observation contrasts with the typical effects of GH, which usually induces hyperinsulinemia.17 Compensatory renal hypertrophy induced by contralateral nephrectomy is accompanied by increased expression of IGF-1 in the remnant kidney, but not by serum or liver expression;18 suggesting that the renal anabolic effects of IGF-1 are likely triggered locally, through binding to specific receptors in the kidney