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In preclinical testing, a selective H 3 -receptor antagonist, A-331440, at oral doses of 5 mg/kg and 15 mg/kg b.i.d, induced significant weight loss in mice raised on a high-fat diet, with the highest dose reducing weight to levels comparable to mice raised on a low-calorie diet
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Weeks 13-24: Primary weight loss phase This is where the combination begins to show its potential
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