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If a baseline integrase genotype does not show evidence of INSTI resistance, one can then change the boosted darunavir to a recommended INSTI, such as dolutegravir or bictegravir

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found that tissue-resident memory T cells producing IL-17 are CD8 + CD49a - , which are highly associated with psoriasis, while the tissue-resident memory T cells in vitiligo lesions are CD8 + CD49a + , suggesting that IL-17-targeted therapy is effective for psoriasis but not for vitiligo (Cheuk et al., 2017)