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Thiobarbituric acid 0.67% (w v -1 ) was added to aliquots of the homogenate previously precipitated with 10% trichloroacetic acid (TCA) (w v -1 )

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The dual mechanism produces additive or combined effects on energy balance -- GIPR activation in the CNS may enhance the anorectic signals from GLP-1R activation, and peripheral GIPR signaling improves adipose tissue function and lipid handling in ways GLP-1 alone does not