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Their activation occurs through different pathways including phosphorylation of cytosolic regulatory subunits by protein kinase C, protein kinase A, phosphatidylinositol-3-kinase (PI3K), mitogen-activated protein kinases (MAPK), and non-receptor associated protein kinases, such as Janus kinase (JAK) and Src, the non-receptor tyrosine kinases (Manea et al., 2015)

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