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In particular, TNF-α plays a dichotomous role in the liver, where it not only induces hepatocyte proliferation and liver regeneration but also acts as a mediator of cell death (Schwabe and Brenner, 2006)
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In a mouse model of lung adenocarcinoma, a dual inhibition of VEGFR and MET pathways has shown potential in delaying resistance and maintaining vascular integrity 174
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