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This formulation enhances ECM metabolism by upregulating Aggrecan and Collagen II while suppressing MMP13 and ADAMTS5

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Through paracrine/autocrine mechanisms, EPO signaling subsequently activates and upregulates efferocytosis-related molecules via peroxisome proliferator-activated receptor gamma (PPARg) activation, including Mer tyrosine kinase (MerTK) and growth arrest-specific 6 (Gas6), among others, thus priming the cells for efficient efferocytosis (Wang et al., 2021)