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On TB-500 the identity problem is severe and the identity test is easy , so everything expensive about verifying it is a choice the seller made — there is no technical excuse for a vendor not knowing which of two molecules 4,074 daltons apart it is shipping

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Some reversions, such as Arg242Tyr and Phe244Leu, substantially reduced activity on GD_M, whereas others, particularly in regions spanning residues 1–67 and 314–439, maintained or improved activity (Supplementary Fig