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Aberrant, mesenchymal-epithelial transition factor (c-MET) signal transduction favors HNSCC progression by stimulating proliferation, motility, invasiveness, morphogenesis, and angiogenesis

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The idea is that phosphorylated uncoupled MOR accumulates at the cell surface when dephosphorylation and recovery from desensitization requires endocytosis (Schulz et al., 2004)