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Teratogenicity assessment in pregnant rats found no effects on fetuses or organ development
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The same goes for hormones.” Start BHRT based on cycle pattern and phase: Early perimenopause: Biest 0.8–1 mg/mL + oral progesterone 100 mg Late perimenopause: Biest 1.5–3 mg/mL + oral progesterone 100–150 mg Menopause: Biest 3–4.5 mg/mL + daily progesterone 100–150 mg → Dose upward slowly and let symptoms guide adjustments
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