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Interactions with the development of serotonin syndrome or neuroleptic malignant syndrome have been described when trazodone is used concomitantly with drugs that have serotonergic activity, such as other antidepressants (e.g., tricyclic antidepressants, selective serotonin reuptake inhibitors, selective serotonin-norepinephrine reuptake inhibitors, and MAO inhibitors) and antipsychotics

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(2011) mapped this mechanism in detail directly on isolated tenocytes in a laboratory dish