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Research shows that around 50 percent to 60 percent of ingested vitamin B12 is usually absorbed when enough intrinsic factor is present in relation to B12, but absorption decreases drastically when this ratio changes

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[ 3 ] Interestingly, one study that measured circulating DSIP levels in humans found that levels were actually lowest at night and highest in the afternoon, which was the opposite of what would be expected for a straightforward sleep-promoting factor