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By contrast, MIC blends used for weight loss are compounded formulas (ingredients and doses vary by clinic) and are not FDA-approved as weight-loss drugs

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In mice, oral bioavailability was 3.5%, and the oral peak blood concentration was 14.5 ng/mL against a mouse NNMT IC50 of 78 ng/mL — meaning the oral route never reached the concentration that inhibits the target enzyme