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Disclosure of interest: Pier Andrea Rizzo: nothing to disclose Poster Session II - NOVEL TARGET/ EXPERIMENTAL FIDINGS TO CLINICAL TRANSLATION 06.00 - NOVEL TARGET/ EXPERIMENTAL FIDINGS TO CLINICAL TRANSLATION - 06.01 - PATHOPHYSIOLOGY OF STROKE / TRANSLATIONAL MEDICINE P1074 - ESOC25-2189 ACTIVATED LEUCOCYTE CELL ADHESION MOLECULE IN MALIGNANT MIDDLE CEREBRAL ARTERY INFARCTION Alejandro Rodríguez Vázquez 1,2,3 , Andrea Cabero-Arnold 1,2 , Carlos Laredo 1,2 , Monica Serrano 1 , Yolanda González Romero 1 , Antonio Doncel-Moriano 1 , Salvatore Rudilosso, Sergio Amaro, Arturo Renú 1 , Laura Llull, Angel Chamorro 1 , Francisco Lozano 2,4 , Xabier Urra 1 1 Comprehensive Stroke Center, Hospital Clínic de Barcelona, Barcelona, Spain, 2 Fundació de Recerca Clínic Barcelona - Institut d'Investigacións Biomèdiques August Pi i Sunyer, Barcelona, Spain, 3 Faculty of Medicine, Universitat de Barcelona, Barcelona, Spain, 4 Centre de Diagnòstic Biomèdic, Hospital Clínic de Barcelona, Barcelona, Spain Background and Aims: Malignant cerebral infarction (MCI) is a devastating situation with no effective treatment besides hemicraniectomy