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Moreover, the shift toward aerobic glycolysis during Mtb infection is linked to the ability of human macrophages to produce mature IL1β, subsequently demonstrated to be essential for bacteriocidal activity against Mtb when glycolysis was blocked with the glycolytic inhibitor 2-deoxyglucose (2-DG) ( Depending on their ontogeny, tissue resident macrophages and infiltrating macrophages have distinct roles, phenotypes and display differential metabolic profiles