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References References Selective and membrane‑permeable small molecule inhibitors of NNMT Roles of Nicotinamide N‑Methyltransferase in Obesity and Type 2 Diabetes Nicotinamide N‑methyltransferase inhibition mimics and boosts exercise‑mediated improvements in muscle function in aged mice Reduced calorie diet combined with NNMT inhibition establishes a healthier gut microbiome in obese mice Kraus et al

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I want to be honest about the evidence here, because this is an area where the research is genuinely mixed, and I think patients are better served by an accurate picture than a simplified one