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PPI safety for long-term use Extended PPI use (longer than 8 weeks at full dose) carries potential risks including magnesium depletion, B12 deficiency, slightly increased fracture risk, and possible kidney effects

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The classical inflammasome pathway involves multiple stages, including inflammasome assembly and activation, channel protein formation, and the maturation and secretion of pro-inflammatory cytokines (e.g., IL1B and IL18)