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The antioxidant system inactivates excess ROS/RNS, causing myogenic regeneration and affecting inflammatory reactions, thus stimulating angiogenesis and reducing fibrosis [75]

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Furthermore, metformin stimulates insulin signaling and glucose transport in muscles while inhibiting critical enzymes involved in gluconeogenesis and glycogen production in the liver when the enzyme adenosine monophosphate kinase (AMPK) is activated[7,25,26]