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The recombinant GHK peptide chelates with a copper ion to form GHK-Cu, where the absorption intensity at 246 nm is continuously raised until the GHK:Cu ratio is 1:1, which means that the concentration of the copper-peptide complex has been saturated (Figure 2C)

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Other mGluR5 antagonists tested in fragile X animal models include CTEC, fenobam and AFQ056